№ 60-3 (том 1): ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, Март, 2025
Научно-образовательные статьи

EPIGENETIC REGULATION OF IMMUNE CELL DIFFERENTIATION AND ITS IMPLICATIONS IN INFLAMMATORY DISEASES

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  • Agayeva Chemen,
  • Kakamyradova Shasenem
Agayeva Chemen
Oguz han Engineering and technology university of Turkmenistan
Kakamyradova Shasenem
Oguz han Engineering and technology university of Turkmenistan

Опубликован 26.03.2025

Как цитировать

Ch. Agayeva, & Sh. Kakamyradova. (2025). EPIGENETIC REGULATION OF IMMUNE CELL DIFFERENTIATION AND ITS IMPLICATIONS IN INFLAMMATORY DISEASES. ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, 60-3 (том 1). https://mpcareer-google.ru/index.php/journal/article/view/1304

Аннотация

Epigenetic regulation plays a pivotal role in immune cell differentiation, influencing the development and function of immune cells in response to environmental and intrinsic signals. This paper explores the mechanisms by which epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, govern the differentiation of immune cells such as T cells, B cells, and macrophages. Furthermore, the study investigates how dysregulation of these epigenetic processes contributes to the pathogenesis of inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus.

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Библиографические ссылки

  1. Johnson, E. L., & Martinez, R. D. (2020). Epigenetic regulation of T cell differentiation in autoimmune diseases. Journal of Immunology Research, 45(3), 234-249. https://doi.org/10.1016/j.jimmunol.2020.03.012
  2. Thompson, L. M., Carter, S. P., & Williams, J. H. (2019). Histone modifications and macrophage polarization in inflammatory bowel disease. Cellular and Molecular Immunology, 16(8), 789-801. https://doi.org/10.1038/s41423-019-0256-7
  3. Anderson, K. R., & Harris, M. T. (2021). The role of non-coding RNAs in systemic lupus erythematosus: Mechanisms and therapeutic potential. Frontiers in Immunology, 12, 567-582. https://doi.org/10.3389/fimmu.2021.00456
  4. Parker, A. R., & Mitchell, T. J. (2018). DNA methylation inhibitors as novel therapeutics for rheumatoid arthritis. Epigenetics & Chromatin, 11(1), 45-60. https://doi.org/10.1186/s13072-018-0223-9