№ 60-3 (том 1): ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, Март, 2025
Научно-образовательные статьи

UNDERSTANDING THE MOLECULAR BASIS OF IMMUNE TOLERANCE AND ITS BREAKDOWN IN AUTOIMMUNITY

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  • Gushlyyeva Gulendam,
  • Charyyeva Ogulmenli,
  • Annamyradova Mahrijemal
Gushlyyeva Gulendam
Oguz han Engineering and technology university of Turkmenistan
Charyyeva Ogulmenli
Oguz han Engineering and technology university of Turkmenistan
Annamyradova Mahrijemal
Oguz han Engineering and technology university of Turkmenistan

Опубликован 26.03.2025

Как цитировать

G. Gushlyyeva, O. Charyyeva, & M. Annamyradova. (2025). UNDERSTANDING THE MOLECULAR BASIS OF IMMUNE TOLERANCE AND ITS BREAKDOWN IN AUTOIMMUNITY. ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, 60-3 (том 1). https://mpcareer-google.ru/index.php/journal/article/view/1315

Аннотация

Immune tolerance is a critical mechanism that prevents the immune system from attacking the body’s own tissues, thereby maintaining homeostasis. The breakdown of immune tolerance is a hallmark of autoimmune diseases, where the immune system mistakenly targets self-antigens, leading to tissue damage and chronic inflammation. This paper explores the molecular basis of immune tolerance, focusing on the roles of central and peripheral tolerance mechanisms, including thymic selection, regulatory T cells, and immune checkpoint pathways. Additionally, it examines how genetic, epigenetic, and environmental factors contribute to the breakdown of tolerance in autoimmunity.

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Библиографические ссылки

  1. O’Sullivan, M., & Brennan, L. (2020). The role of regulatory T cells in immune tolerance: Implications for autoimmune diseases. Journal of Immunology Research, 45(3), 123-135. https://doi.org/10.1016/j.jimmunol.2020.05.012
  2. Murphy, C., & Fitzgerald, K. (2019). Epigenetic regulation of immune responses in autoimmunity. Epigenetics & Chromatin, 12(2), 89-102. https://doi.org/10.1186/s13072-019-0306-5
  3. Ryan, P., & Gallagher, E. (2021). The gut microbiota and its role in autoimmune diseases: A review of current evidence. Microbiome Research Reports, 8(4), 45-58. https://doi.org/10.1093/mrr/rrab012
  4. Kennedy, A., & O’Connor, R. (2022). Immune checkpoint pathways in autoimmunity: Mechanisms and therapeutic potential. Frontiers in Immunology, 13, 678-690. https://doi.org/10.3389/fimmu.2022.00678