№ 61-1 (том 1): ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, Апрель, 2025
Научно-образовательные статьи

TECHNOLOGIES FOR THE PRODUCTION OF PHARMACEUTICAL-GRADE SODIUM CHLORIDE

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  • Ekayev Mukam,
  • Rozyyeva Merjen,
  • Amanova Guncha
Ekayev Mukam
Oguz han Engineering and technology university of Turkmenistan
Rozyyeva Merjen
Oguz han Engineering and technology university of Turkmenistan
Amanova Guncha
Oguz han Engineering and technology university of Turkmenistan

Опубликован 24.04.2025

Как цитировать

M. Ekayev, M. Rozyyeva, & G. Amanova. (2025). TECHNOLOGIES FOR THE PRODUCTION OF PHARMACEUTICAL-GRADE SODIUM CHLORIDE. ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, 61-1 (том 1). https://mpcareer-google.ru/index.php/journal/article/view/1639

Аннотация

Pharmaceutical-grade sodium chloride (*NaCl*) is widely used in medicine, pharmacology, and biotechnology. Its production requires strict quality control, compliance with regulatory standards, and advanced purification technologies. This paper examines the primary methods for producing high-purity sodium chloride, including evaporation, recrystallization, and membrane technologies. Key factors influencing the final product quality, as well as the applicable pharmacopoeial standards (USP, Ph. Eur., JP), are analyzed. Particular attention is given to modern trends aimed at improving technological processes and ensuring environmental sustainability.

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Библиографические ссылки

  1. United States Pharmacopeia (USP 43). "Sodium Chloride Monograph." The United States Pharmacopeial Convention, 2020.
  2. European Pharmacopoeia (Ph. Eur. 10.0). "Sodium Chloride for Pharmaceutical Use." European Directorate for the Quality of Medicines, 2020.
  3. Japanese Pharmacopoeia (JP 17). "Sodium Chloride – Specifications and Quality Control." Ministry of Health, Labour and Welfare, Japan, 2019.
  4. Mauer, L. J., & Taylor, L. S. (2010). "Water-Soluble Ionic Contaminants in Pharmaceutical Salts." *Journal of Pharmaceutical Sciences, 99*(2), 746–759.
  5. Czégény, Z., Nagy, T., & Kótai, L. (2018). "Advances in the Purification of Sodium Chloride for Medical Applications." *Chemical Engineering Journal, 350*, 451–460.