Опубликован 26.10.2025
Как цитировать
Аннотация
Restoring lost function is a central challenge in modern biomedicine, combining regenerative medicine, tissue engineering, and neuroprosthetics to repair damaged tissues and restore sensory, motor, and cognitive capabilities. This review analyzes the evolution of approaches to functional restoration, from historical methods to cutting-edge technologies such as stem cell therapy, extracellular matrix modification, 3D bioprinting, and brain-computer interfaces (BCIs). Based on bibliometric analysis and key studies, it highlights trends in interdisciplinary collaboration, technological breakthroughs, and challenges, including immunogenicity, biocompatibility, and long-term integration. The article draws on publications from 2010–2025, demonstrating a 15% annual growth in research output, with a shift from symptomatic treatment to regenerative strategies. Keywords: functional restoration, regenerative medicine, neuroprosthetics, stem cells, brain-computer interfaces, extracellular matrix.
Библиографические ссылки
- Neuroprosthetics: from sensorimotor to cognitive disorders. Nature Communications. 2023. <https://www.nature.com/articles/s42003-022-04390-w>
- Neural tissue engineering: Multi-compartmental scaffold. PubMed. 2023. <https://pubmed.ncbi.nlm.nih.gov/37775532/>
- Motor neuroprostheses. PubMed. 2020. <https://pubmed.ncbi.nlm.nih.gov/32542480/>
- Exploring the potential of stem cell therapy. ScienceDirect. 2025. <https://www.sciencedirect.com/science/article/abs/pii/S0065128125000091>
- Advancements and challenges in stem cell transplantation. ScienceDirect. 2024. <https://www.sciencedirect.com/science/article/pii/S2405844024118671>
- Mesenchymal stem cell secretome for regenerative medicine. ScienceDirect. 2024. <https://www.sciencedirect.com/science/article/pii/S2090123224001814>