№ 67-2 (том 2): ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, Октябрь, 2025
Научно-образовательные статьи

ARTIFICIAL BLOOD: ADVANCES IN BIOMEDICAL ENGINEERING

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  • Selbi Gulmuhammedova,
  • Hojagurbanova Orazgul
Selbi Gulmuhammedova
OGUZ HAN ENGINEERING AND TECHNOLOGY UNIVERSITY OF TURKMENISTAN
Hojagurbanova Orazgul
OGUZ HAN ENGINEERING AND TECHNOLOGY UNIVERSITY OF TURKMENISTAN

Опубликован 26.10.2025

Ключевые слова

  • artificial blood, blood substitutes, hemoglobin-based oxygen carriers, perfluorocarbons, stem cell-derived RBCs, transfusion medicine.

Как цитировать

S. Gulmuhammedova, & O. Hojagurbanova. (2025). ARTIFICIAL BLOOD: ADVANCES IN BIOMEDICAL ENGINEERING. ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, 67-2 (том 2). https://mpcareer-google.ru/index.php/journal/article/view/3528

Аннотация

Artificial blood represents a transformative innovation in transfusion medicine, integrating biochemistry, nanotechnology, and stem cell engineering to create oxygen-carrying substitutes that overcome limitations of donor blood. This review examines the historical evolution from early HBOCs to contemporary advancements, including polymerized hemoglobins, PFCs, and bioengineered RBCs. Based on bibliometric analyses and clinical data from 1960–2025, it highlights key trends in development, such as improved biocompatibility and extended storage, with products achieving clinical approvals in select regions. Challenges like toxicity and scalability are addressed, alongside future directions in AI-optimized formulations and universal donors. 

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Библиографические ссылки

  1. The evolution of artificial red blood cells and recent advances in state-of-the-art oxygen carrier technologies: a narrative review. PMC. 2025. <https://pmc.ncbi.nlm.nih.gov/articles/PMC12435547/>
  2. Progress in Development of Functional Biological and Synthetic Blood Products. PMC. 2025. <https://pmc.ncbi.nlm.nih.gov/articles/PMC11939705/>
  3. Scientists are developing artificial blood that could save lives. NPR. 2025. <https://www.npr.org/sections/shots-health-news/2025/07/24/nx-s1-5477632/artificial-blood-hemorrhage-emergency-medicine>
  4. $2.7M NIH grant to fund next generation of synthetic blood. PSU. 2025. <https://www.psu.edu/news/research/story/27m-nih-grant-fund-next-generation-synthetic-blood>
  5. The ultimate blood substitute? The U.S. military is betting $46 million. Science. 2024. <https://www.science.org/content/article/ultimate-blood-substitute-us-military-betting-46-million>