Опубликован 12.05.2026
Ключевые слова
- Artemisia absinthium, absyntol, sesquiterpene lactones, absinthin, artabsin, thujone, phytopharmaceutical extraction, percolation, choleretic preparation, standardization.
Как цитировать
Аннотация
Absyntol is a standardized phytopharmaceutical preparation derived from the aerial parts of Artemisia absinthium L. (common wormwood, family Asteraceae), characterized primarily by its content of sesquiterpene lactones — most notably absinthin and artabsin — alongside essential oils rich in thujone, azulene precursors, and phenolic compounds. The preparation has well-documented choleretic, digestive, anti-inflammatory, anthelmintic, and antimicrobial activities, and has been utilized in traditional and evidence-based phytotherapy since the nineteenth century.
This article presents a comprehensive description of the industrial and laboratory technological process for obtaining absyntol: from botanical raw material preparation, through maceration and percolation extraction, solvent fractionation, concentration, and standardization, to final quality control procedures. Physicochemical parameters, yield calculations, and critical process variables are discussed. The article draws on pharmacopoeial monographs, current phytochemical literature, and industrial pharmaceutical technology.
Библиографические ссылки
- European Pharmacopoeia, 11th edition. (2023). Absinthii herba (01/2023:0763). European Directorate for the Quality of Medicines & HealthCare (EDQM), Strasbourg.
- State Pharmacopoeia of the Russian Federation, 14th edition. (2018). Articles FS.2.5.0003.18 and FS.2.5.0005.18. Ministry of Health of the Russian Federation, Moscow.
- ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products. (2003). Absinthii herba (Wormwood). European Scientific Cooperative on Phytotherapy, Thieme, Stuttgart.
- Juteau, F., Masotti, V., Bessiere, J. M., Dherbomez, M., & Viano, J. (2002). Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia, 73(6), 532-535.
- Lachenmeier, D. W., Emmert, J., Kuballa, T., & Sartor, G. (2006). Thujone -- cause of absinthism? Forensic Science International, 158(1), 1-8.
- Negru, I., & Neacsu, I. (2015). Phytochemistry and pharmacology of Artemisia absinthium. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 43(1), 324-333.
- Penzak, S. R., Jann, M. W., Cold, J. A., Hon, Y. Y., Desai, H. D., & Kashuba, A. D. (2000). Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. Journal of Clinical Pharmacology, 41(10), 1059-1063.
- Tan, R., Zheng, W., & Tang, H. (1998). Biologically active substances from the genus Artemisia. Planta Medica, 64(4), 295-302.
- Vanaclocha, B., & Canigueral, S. (Eds.). (2016). Fitoterapia: Vademecum de Prescripcion, 5th ed. Elsevier, Barcelona. [Cross-referenced for sesquiterpene lactone standardization methods.]
- Wichtl, M. (Ed.). (2004). Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd ed. Medpharm Scientific Publishers, Stuttgart.