№ 74-1 (том 2): ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, Май, 2026
Научно-образовательные статьи

TECHNOLOGY OF COUMARIN EXTRACTION FROM FOENICLUM VILGARE

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  • Atayeva Cheper,
  • Annajanova Altyn
Atayeva Cheper
OGUZ HAN ENGINEERING AND TECHNOLOGY UNIVERSITY OF TURKMENISTAN
Annajanova Altyn
OGUZ HAN ENGINEERING AND TECHNOLOGY UNIVERSITY OF TURKMENISTAN

Опубликован 12.05.2026

Ключевые слова

  • Foeniculum vulgare, fennel, coumarin extraction, umbelliferone, bergapten, furocoumarin, solvent extraction, column chromatography, HPLC, phytopharmaceutical technology.

Как цитировать

Ch. Atayeva, & A. Annajanova. (2026). TECHNOLOGY OF COUMARIN EXTRACTION FROM FOENICLUM VILGARE. ОБРАЗОВАНИЕ И НАУКА В XXI ВЕКЕ, 74-1 (том 2). https://mpcareer-google.ru/index.php/journal/article/view/5502

Аннотация

Foeniculum vulgare Mill. (fennel, family Apiaceae) is a commercially and medicinally important aromatic plant whose fruits (commonly called seeds) serve as the principal source of pharmaceutical-grade fennel essential oil and a range of secondary metabolites. Among these, coumarins — particularly umbelliferone (7-hydroxycoumarin), bergapten (5-methoxypsoralen), isopimpinellin, and psoralen — represent a pharmacologically significant fraction with documented spasmolytic, anti-inflammatory, photosensitizing, and anticoagulant activities. Despite the dominance of trans-anethole and fenchone in fennel's phytochemical profile, the coumarin fraction has attracted increasing pharmaceutical and cosmetic interest.

This article presents a detailed technical description of the industrial and laboratory-scale process for extracting, isolating, and purifying coumarins from F. vulgare fruits: from botanical raw material preparation through solvent extraction, liquid-liquid partitioning, column chromatographic isolation, crystallization, and quality control by HPLC and spectroscopic methods. Process parameters, yield data, and critical technological variables are discussed with reference to current pharmacopoeial and scientific literature.

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Библиографические ссылки

  1. European Pharmacopoeia, 11th edition. (2023). Foeniculi fructus (01/2016:0824). European Directorate for the Quality of Medicines & HealthCare (EDQM), Strasbourg.
  2. Gori, L., Gallo, E., Mascherini, V., Mugelli, A., Vannacci, A., & Firenzuoli, F. (2012). Can estragole in fennel seed decoctions really be considered a danger for human health? A fennel safety update. Evidence-Based Complementary and Alternative Medicine, 2012, 860542.
  3. Hammer, K. A., Carson, C. F., & Riley, T. V. (1999). Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology, 86(6), 985-990.
  4. Harborne, J. B., & Williams, C. A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 55(6), 481-504.
  5. Kite, G. C., Grayer, R. J., Veitch, N. C., & Simmonds, M. S. J. (2003). The potential of metabolomics for the authentication of natural products. Phytochemical Analysis, 14(5), 227-234.
  6. Kosalec, I., Pepeljnjak, S., & Kustrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharmaceutica, 55(4), 377-385.
  7. Marotti, M., Piccaglia, R., & Giovanelli, E. (1994). Differences in essential oil composition of basil (Ocimum basilicum L.) Italian cultivars related to morphological characteristics. Journal of Agricultural and Food Chemistry, 42(12), 2555-2560.
  8. Mimica-Dukic, N., & Bozin, B. (2008). Fennel (Foeniculum vulgare Mill.) as a raw material in pharmaceutical industry. In N. Govil & V. Singh (Eds.), Recent Progress in Medicinal Plants (Vol. 21). Studium Press, Houston.
  9. Stavri, M., & Gibbons, S. (2005). The antimycobacterial constituents of dill (Anethum graveolens). Phytotherapy Research, 19(11), 938-941.
  10. Wichtl, M. (Ed.). (2004). Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd ed. Medpharm Scientific Publishers, Stuttgart.
  11. Zobel, A. M., & Brown, S. A. (1991). Coumarins in the surface waxes of Ruta graveolens and related plants. Journal of Natural Products, 54(4), 1025-1033.